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FOX04-DRI
FOX04-DRI Injectable (Research Use Only)
High-Purity Research Formula for Laboratory Applications
Product Description:
What is FOXO4-DRI
FOXO4-DRI is a synthetic peptide designed to eliminate senescent cells by disrupting the interaction between FOXO4 and p53. Normally, FOXO4 prevents p53 from triggering apoptosis in ageing cells, allowing them to persist and contribute to age-related diseases.
By interfering with this process, FOXO4-DRI frees p53, leading to selective apoptosis of senescent cells without harming healthy ones.
Research in animal models suggests it may improve tissue function, enhance organ health, and promote longevity.
Molecular Formula: C228H388N86O64
Amino Acid Sequence: H-LTLRKEPASEIAQSIL EAYSQNGWANRRSGGK RPPPRRRQRRKRG-OH
Molecular Weight: 5358.05 g/mol
Potential Benefits of FOXO4-DRI
During clinical studies, FOXO4-DRI has demonstrated the following benefits:
- May slow the ageing process by targeting senescent cells
- Improves the function of certain organs, including the kidneys
- Could reduce chronic inflammation
- Supports hair regrowth
- Could reduce the risk of neurodegenerative disorders
- May help with the repair and regeneration of muscle tissue
FAQs
Is FOXO4-DRI part of the forkhead peptide family?
Yes, FOXO4-DRI is related to the forkhead peptide family. Specifically, it is derived from the FOXO (Forkhead box O) family of transcription factors, which are part of the larger forkhead family. These transcription factors play a critical role in regulating various cellular processes, including apoptosis (programmed cell death), oxidative stress response, and cell cycle regulation.
FOXO4, a member of this family, interacts with the p53 protein to help senescent cells avoid apoptosis. FOXO4-DRI is a modified version of this interaction domain, designed to disrupt the FOXO4-p53 binding. This disruption allows senescent cells to undergo apoptosis, making FOXO4-DRI a promising senolytic agent for anti-ageing and therapeutic applications.
What is peptide synthesis?
Peptide synthesis is the process of creating peptides, which are short chains of amino acids linked by peptide bonds. These chains are the building blocks of proteins and play crucial roles in biological processes, such as signalling, immune responses, and tissue repair.
Could FOXO4-DRI act as a tumour suppressor?
FOXO4-DRI has potential as a tumor suppressor due to its ability to target and eliminate senescent cells, which are often associated with a pro-inflammatory environment that can promote tumor growth. Senescent cells secrete factors known as the senescence-associated secretory phenotype (SASP), which can contribute to chronic inflammation and create a microenvironment favorable for cancer progression.
By disrupting the interaction between FOXO4 and p53, FOXO4-DRI induces apoptosis (programmed cell death) in senescent cells, reducing their harmful effects. This mechanism could theoretically help suppress tumor development by removing cells that might otherwise contribute to a cancer-friendly environment. However, while preclinical studies show promise, more research is needed to fully understand its role and efficacy as a tumor suppressor in humans.
What peptides could FOXO4-DRI be stacked with?
FOXO4-DRI could potentially be stacked with other peptides that complement its senolytic (senescent cell-clearing) properties to enhance overall health and anti-aging effects.
Here are some examples:
1. Epitalon: Known for its anti-aging properties, the Epitalon peptidepromotes telomere lengthening and supports cellular repair, which could synergize with FOXO4-DRI’s senescent cell-clearing effects.
2. Thymosin Alpha-1 (Tα1): This peptide boosts immune function and reduces inflammation, which could work well alongside FOXO4-DRI to improve the body’s response to aging and chronic conditions. Buy Thymosin Alpha-1.
3. BPC-157: A peptide known for its regenerative properties, the BPC-157 peptide could complement FOXO4-DRI by promoting tissue repair and healing, especially in areas affected by senescent cell accumulation.
4. GHK-Cu: This copper peptide supports skin regeneration, wound healing, and anti-inflammatory effects, making it a good partner for FOXO4-DRI in anti-aging protocols.
5. CJC-1295/Ipamorelin: These growth hormone-releasing peptides could enhance tissue repair and regeneration, potentially amplifying the rejuvenating effects of FOXO4-DRI.
6. NAD+ Boosters (e.g., NMN or NR): While not peptides, NAD+ precursors can be stacked with FOXO4-DRI to support mitochondrial function and cellular energy, complementing its senolytic action.
When considering peptide stacks, it’s crucial to consult with a healthcare professional or researcher experienced in peptide therapies to ensure safety, proper dosing, and compatibility. Most of these peptides are still in the research phase and not approved for human use.
RevitaLife supplies peptides to the research industry only, with worldwide shipping.
Scientific Research
(1) Al-Naggar IMA, Kuchel GA, Xu M. Senolytics: targeting senescent cells for age-associated diseases. Curr Mol Biol Rep. 2020 Dec;6(4):161-172. doi: 10.1007/s40610-020-00140-1.
(2) Bourgeois B, Madl T. Regulation of cellular senescence via the FOXO4-p53 axis. FEBS Lett. 2018 Jun;592(12):2083-2097.
(3) Zhang C, Xie Y, Chen H, Lv L, Yao J, Zhang M, Xia K, Feng X, Li Y, Liang X, Sun X, Deng C, Liu G. FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice. Aging (Albany NY). 2020 Jan 20;12(2):1272-1284.
(4) Lucía Antelo-Iglesias, Pilar Picallos-Rabina, Valentín Estévez-Souto, Sabela Da Silva-Álvarez, Manuel Collado, The role of cellular senescence in tissue repair and regeneration, Mechanisms of Ageing and Development, Volume 198, 2021.
(5) Tan H, Xu J, Liu Y. Ageing, cellular senescence and chronic kidney disease: experimental evidence. Curr Opin Nephrol Hypertens. 2022 May 1;31(3):235-243.
(6) Xu J, Zhou L, Liu Y. Cellular Senescence in Kidney Fibrosis: Pathologic Significance and Therapeutic Strategies. Front Pharmacol. 2020 Dec 11;11:601325.
(7) Kong YX, Li ZS, Liu YB, Pan B, Fu X, Xiao R, Yan L. FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation. Commun Biol. 2025 Feb 24;8(1):299.
Peptide Storage & Reconstitution
The Peptide Vial holds a white, lyophilised solid peptide that dissolves easily in clinical-grade sterile or bacteriostatic water.
To preserve the quality and stability of peptides, store them in a cool, dry place, away from heat and direct sunlight.
Refrigeration is highly recommended, with optimal storage temperatures between 2°C and 8°C.
Keeping peptides in tightly sealed vials or containers prevents exposure to air and moisture, which can compromise their quality.
Following these storage guidelines helps extend the shelf life of peptides, ensuring their reliability for research and therapeutic use.
ALL PRODUCT INFORMATION AND ARTICLES ON THIS SITE ARE FOR EDUCATIONAL PURPOSES ONLY
DISCLAIMER:
All products sold by Revitalife are for research and laboratory use only.
These products are not designed for use or consumption by humans or animals.
They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.
By purchasing from our website the buyer accepts and acknowledges the risks involved with handling of these products.
All articles and product information provided on this Website are for informational and educational purposes only. Handling and use of these products should be restricted to suitably qualified professionals.
FOX04-DRI Injectable (Research Use Only)
High-Purity Research Formula for Laboratory Applications
Product Description:
What is FOXO4-DRI
FOXO4-DRI is a synthetic peptide designed to eliminate senescent cells by disrupting the interaction between FOXO4 and p53. Normally, FOXO4 prevents p53 from triggering apoptosis in ageing cells, allowing them to persist and contribute to age-related diseases.
By interfering with this process, FOXO4-DRI frees p53, leading to selective apoptosis of senescent cells without harming healthy ones.
Research in animal models suggests it may improve tissue function, enhance organ health, and promote longevity.
Molecular Formula: C228H388N86O64
Amino Acid Sequence: H-LTLRKEPASEIAQSIL EAYSQNGWANRRSGGK RPPPRRRQRRKRG-OH
Molecular Weight: 5358.05 g/mol
Potential Benefits of FOXO4-DRI
During clinical studies, FOXO4-DRI has demonstrated the following benefits:
- May slow the ageing process by targeting senescent cells
- Improves the function of certain organs, including the kidneys
- Could reduce chronic inflammation
- Supports hair regrowth
- Could reduce the risk of neurodegenerative disorders
- May help with the repair and regeneration of muscle tissue
FAQs
Is FOXO4-DRI part of the forkhead peptide family?
Yes, FOXO4-DRI is related to the forkhead peptide family. Specifically, it is derived from the FOXO (Forkhead box O) family of transcription factors, which are part of the larger forkhead family. These transcription factors play a critical role in regulating various cellular processes, including apoptosis (programmed cell death), oxidative stress response, and cell cycle regulation.
FOXO4, a member of this family, interacts with the p53 protein to help senescent cells avoid apoptosis. FOXO4-DRI is a modified version of this interaction domain, designed to disrupt the FOXO4-p53 binding. This disruption allows senescent cells to undergo apoptosis, making FOXO4-DRI a promising senolytic agent for anti-ageing and therapeutic applications.
What is peptide synthesis?
Peptide synthesis is the process of creating peptides, which are short chains of amino acids linked by peptide bonds. These chains are the building blocks of proteins and play crucial roles in biological processes, such as signalling, immune responses, and tissue repair.
Could FOXO4-DRI act as a tumour suppressor?
FOXO4-DRI has potential as a tumor suppressor due to its ability to target and eliminate senescent cells, which are often associated with a pro-inflammatory environment that can promote tumor growth. Senescent cells secrete factors known as the senescence-associated secretory phenotype (SASP), which can contribute to chronic inflammation and create a microenvironment favorable for cancer progression.
By disrupting the interaction between FOXO4 and p53, FOXO4-DRI induces apoptosis (programmed cell death) in senescent cells, reducing their harmful effects. This mechanism could theoretically help suppress tumor development by removing cells that might otherwise contribute to a cancer-friendly environment. However, while preclinical studies show promise, more research is needed to fully understand its role and efficacy as a tumor suppressor in humans.
What peptides could FOXO4-DRI be stacked with?
FOXO4-DRI could potentially be stacked with other peptides that complement its senolytic (senescent cell-clearing) properties to enhance overall health and anti-aging effects.
Here are some examples:
1. Epitalon: Known for its anti-aging properties, the Epitalon peptidepromotes telomere lengthening and supports cellular repair, which could synergize with FOXO4-DRI’s senescent cell-clearing effects.
2. Thymosin Alpha-1 (Tα1): This peptide boosts immune function and reduces inflammation, which could work well alongside FOXO4-DRI to improve the body’s response to aging and chronic conditions. Buy Thymosin Alpha-1.
3. BPC-157: A peptide known for its regenerative properties, the BPC-157 peptide could complement FOXO4-DRI by promoting tissue repair and healing, especially in areas affected by senescent cell accumulation.
4. GHK-Cu: This copper peptide supports skin regeneration, wound healing, and anti-inflammatory effects, making it a good partner for FOXO4-DRI in anti-aging protocols.
5. CJC-1295/Ipamorelin: These growth hormone-releasing peptides could enhance tissue repair and regeneration, potentially amplifying the rejuvenating effects of FOXO4-DRI.
6. NAD+ Boosters (e.g., NMN or NR): While not peptides, NAD+ precursors can be stacked with FOXO4-DRI to support mitochondrial function and cellular energy, complementing its senolytic action.
When considering peptide stacks, it’s crucial to consult with a healthcare professional or researcher experienced in peptide therapies to ensure safety, proper dosing, and compatibility. Most of these peptides are still in the research phase and not approved for human use.
RevitaLife supplies peptides to the research industry only, with worldwide shipping.
Scientific Research
(1) Al-Naggar IMA, Kuchel GA, Xu M. Senolytics: targeting senescent cells for age-associated diseases. Curr Mol Biol Rep. 2020 Dec;6(4):161-172. doi: 10.1007/s40610-020-00140-1.
(2) Bourgeois B, Madl T. Regulation of cellular senescence via the FOXO4-p53 axis. FEBS Lett. 2018 Jun;592(12):2083-2097.
(3) Zhang C, Xie Y, Chen H, Lv L, Yao J, Zhang M, Xia K, Feng X, Li Y, Liang X, Sun X, Deng C, Liu G. FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice. Aging (Albany NY). 2020 Jan 20;12(2):1272-1284.
(4) Lucía Antelo-Iglesias, Pilar Picallos-Rabina, Valentín Estévez-Souto, Sabela Da Silva-Álvarez, Manuel Collado, The role of cellular senescence in tissue repair and regeneration, Mechanisms of Ageing and Development, Volume 198, 2021.
(5) Tan H, Xu J, Liu Y. Ageing, cellular senescence and chronic kidney disease: experimental evidence. Curr Opin Nephrol Hypertens. 2022 May 1;31(3):235-243.
(6) Xu J, Zhou L, Liu Y. Cellular Senescence in Kidney Fibrosis: Pathologic Significance and Therapeutic Strategies. Front Pharmacol. 2020 Dec 11;11:601325.
(7) Kong YX, Li ZS, Liu YB, Pan B, Fu X, Xiao R, Yan L. FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation. Commun Biol. 2025 Feb 24;8(1):299.
Peptide Storage & Reconstitution
The Peptide Vial holds a white, lyophilised solid peptide that dissolves easily in clinical-grade sterile or bacteriostatic water.
To preserve the quality and stability of peptides, store them in a cool, dry place, away from heat and direct sunlight.
Refrigeration is highly recommended, with optimal storage temperatures between 2°C and 8°C.
Keeping peptides in tightly sealed vials or containers prevents exposure to air and moisture, which can compromise their quality.
Following these storage guidelines helps extend the shelf life of peptides, ensuring their reliability for research and therapeutic use.
ALL PRODUCT INFORMATION AND ARTICLES ON THIS SITE ARE FOR EDUCATIONAL PURPOSES ONLY
DISCLAIMER:
All products sold by Revitalife are for research and laboratory use only.
These products are not designed for use or consumption by humans or animals.
They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.
By purchasing from our website the buyer accepts and acknowledges the risks involved with handling of these products.
All articles and product information provided on this Website are for informational and educational purposes only. Handling and use of these products should be restricted to suitably qualified professionals.