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GHK-CU
GHK-Cu (Copper Peptide) – Research Grade
For Research Use Only – Not for Human or Veterinary Use
What is GHK-Cu Peptide?
GHK-Cu, a tripeptide complex naturally found in the human plasma, is composed of glycine, histidine, and lysine bonded with copper. This peptide is integral to skin health and repair, as it stimulates collagen production, enhancing skin elasticity and firmness (1).
Its anti-inflammatory properties aid in reducing skin irritation and promote faster wound healing. Moreover, GHK-Cu supports hair growth by revitalizing hair follicles, making it beneficial in treating hair thinning (1).
Widely utilized in cosmetic and therapeutic applications, GHK-Cu is valued for its anti-aging benefits, offering comprehensive skin rejuvenation and contributing to healthier, more youthful-looking skin.
Molecular Formula: C14H24N6O4
Sequence: H-Gly-His-Lys-OH
Molecular Weight: 340.38 g/mol
View the HPLC Certificate here.
Source:
Summary of GHK-Cu Benefits:
During clinical studies GHK-Cu demonstrate the following potential benefits:
Enhances collagen production which can enhance skin elasticity and firmness (2).
Promotes wound healing of various soft tissues (1).
Decreases inflammation of skin which can reduce redness and inflamed skin (3).
Reduces the signs of aging through improving skin elasticity and firmness (4).
Supports hair growth (1).
Protects against oxidative stress (5).
Potential treatment for neurological diseases and cognitive impairment (6).
GHK-Cu Mechanism of Action
GHK-Cu peptide functions by interacting with cells to promote skin health and repair through several mechanisms. It binds copper ions, a crucial element for cellular processes, allowing GHK-Cu to enhance enzymatic activities essential for tissue regeneration.
This interaction stimulates collagen production, which is vital for maintaining skin elasticity and firmness (1).
This amino acids anti-inflammatory effects help reduce skin irritation and facilitate faster wound healing by modulating immune response and decreasing cytokine production.
Additional information suggests that GHK-Cu influences gene expression related to skin regeneration, activating genes that promote skin repair and recovery (3).
Its antioxidant properties further protective effects on skin cells from oxidative stress by neutralizing free radical damage, which is one of the primary contributors to premature aging and skin damage (5). Through these combined actions, GHK-Cu not only supports skin rejuvenation but also contributes to overall skin vitality, making it a valuable component in both cosmetic and therapeutic applications aimed at enhancing skin health and appearance.
Potential Clinical Applications of GHK-Cu Peptide
UK Laboratory studies have found that GHK-Cu that GHK-Cu can have the following clinical applications:
Enhances Collagen Synthesis
Studies have identified that GHK-Cu significantly enhances collagen production and offers anti-aging benefits by activating fibroblasts, the skin cells responsible for collagen synthesis. This results in increased production of collagen levels, improving skin elasticity and reducing the appearance of wrinkles (1). Its powerful antioxidant properties protect skin cells from oxidative stress, which can accelerate aging (5). Additionally, GHK-Cu prevents enzymes like matrix metalloproteinases that break down collagen, preserving the skin’s structural integrity. These combined actions contribute to a firmer, more youthful skin appearance, making GHK-Cu an essential ingredient in anti-aging skincare products.
Promotes Hair Growth
When used in a scalp serum treatment GHK-Cu promotes hair growth by stimulating hair follicles and improving blood flow to the scalp, ensuring essential nutrients reach the follicles (1). It reduces inflammation and oxidative stress, creating a healthier environment for hair growth. Additionally, GHK-Cu enhances collagen production, strengthening the scalp, improves hair follicle size and supports robust hair structure.
Accelerates Wound Healing
GHK-Cu, or Glycyl-L-histidyl-L-lysine copper, accelerates wound healing through several mechanisms. It stimulates the growth of skin cells like keratinocytes and fibroblasts, critical for tissue regeneration. By enhancing collagen production, GHK-Cu provides structural support to healing tissues (1). Its anti-inflammatory effects reduce swelling and promote a conducive healing environment. The peptide also promotes angiogenesis, forming new blood vessels that supply essential nutrients and oxygen to the wound (7). With antioxidant properties, it protects cells from oxidative stress, while its antimicrobial effects lower infection risks. These combined actions make GHK-Cu an effective ingredient in skincare products for wound repair.
Reduces Inflammation and Redness of the Skin
GHK-Cu reduces skin inflammation and redness through several effective mechanisms. It modulates inflammatory cytokines, thereby calming the skin’s inflammatory response and reducing redness (3). Its potent antioxidant properties help neutralize free radicals, protecting skin cells from oxidative stress that can exacerbate inflammation. Additionally, GHK-Cu promotes skin repair by stimulating the regeneration of healthy skin cells, reducing dead skin cells which aids in restoring the natural skin barrier, clarity and appearance (1). These combined actions make GHK-Cu a powerful ingredient in skincare products designed to soothe and improve skin health, offering relief from irritation and contributing to a clearer, more balanced complexion.
Potential Treatment for Cognitive Impairment
GHK-Cu may offer benefits for neurological problems through several promising mechanisms. It reduces oxidative stress, which is crucial for protecting nerve cells from damage associated with neurological disorders (6). Additionally, GHK-Cu promotes nerve regeneration by stimulating the repair and growth of neurons, potentially aiding in recovery from neural injuries. It also modulates inflammatory responses within the nervous system, helping to create a more balanced environment for neuron function (1). These combined actions suggest that GHK-Cu could contribute to neuroprotection and improved cognitive function, positioning it as a valuable compound for supporting neurological health and wellness.
GHK-Cu Frequently Asked Questions
What products is GHK-Cu found in?
The GHK-Cu peptide is found in many hair care, skin care products and dietary supplements. The copper peptide serum is commonly found in eye cream, face serum, moisturisers, vitamin c cream and some formulations containing hyaluronic acid. It is important to check the ingredient lists of products or check with a pharmacist.
What effects on the skin does GHK-Cu peptide products have?
As discussed above, GHK-Cu is extensively studied for its anti-aging effects on the skin. It has been found to improve skin density, thickness, reduce the depth of wrinkles and fine lines particularly around the eye area, reduce large pores, and improve elasticity. Furthermore, GHK-Cu may reduce the appearance of lesions and acne scars.
Can GHK-Cu skin serum reduce the effects of UV radiation?
Clinical trials demonstrate that GHK-Cu skin serum can help reduce the effects of UV radiation. The peptide aids in wound healing and reduces inflammation, which can be beneficial in mitigating the effects of UV exposure (1). a
Scientific Research
(1) Pickart L, Margolina A. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. Int J Mol Sci. 2018 Jul 7;19(7):1987.
(2) Pickart L, Vasquez-Soltero JM, Margolina A. GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration. Biomed Res Int. 2015;2015:648108.
(3) Park JR, Lee H, Kim SI, Yang SR. The tri-peptide GHK-Cu complex ameliorates lipopolysaccharide-induced acute lung injury in mice. Oncotarget. 2016 Sep 6;7(36):58405-58417.
(4) Dou Y, Lee A, Zhu L, Morton J, Ladiges W. The potential of GHK as an anti-aging peptide. Aging Pathobiol Ther. 2020 Mar 27;2(1):58-61.
(5) Pickart L, Vasquez-Soltero JM, Margolina A. The human tripeptide GHK-Cu in prevention of oxidative stress and degenerative conditions of aging: implications for cognitive health. Oxid Med Cell Longev. 2012;2012:324832.
(6) Tucker M, Keely A, Park JY, Rosenfeld M, Wezeman J, Mangalindan R, Ratner D, Ladiges W. Intranasal GHK peptide enhances resilience to cognitive decline in aging mice. bioRxiv [Preprint]. 2023 Nov 17:2023.11.16.567423.
(7) Tianqi Liu, Ying Liu, Xiaoyu Zhao, Liguo Zhang, Wei Wang, De Bai, Ya Liao, Zhenyuan Wang, Mi Wang, Jiaheng Zhang, Thermodynamically stable ionic liquid microemulsions pioneer pathways for topical delivery and peptide application, Bioactive Materials, Volume 32, 2024, Pages 502-513
(8) Malinda KM, Sidhu GS, Mani H, Banaudha K, Maheshwari RK, Goldstein AL, Kleinman HK. Thymosin beta4 accelerates wound healing. J Invest Dermatol. 1999 Sep;113(3):364-8.
Peptide Storage & Reconstitution
The Peptide Vial holds a white, lyophilised solid peptide that dissolves easily in clinical-grade sterile or bacteriostatic water.
To preserve the quality and stability of peptides, store them in a cool, dry place, away from heat and direct sunlight.
Refrigeration is highly recommended, with optimal storage temperatures between 2°C and 8°C.
Keeping peptides in tightly sealed vials or containers prevents exposure to air and moisture, which can compromise their quality.
Following these storage guidelines helps extend the shelf life of peptides, ensuring their reliability for research and therapeutic use.
ALL PRODUCT INFORMATION AND ARTICLES ON THIS SITE ARE FOR EDUCATIONAL PURPOSES ONLY
DISCLAIMER:
All products sold by Revitalife are for research and laboratory use only.
These products are not designed for use or consumption by humans or animals.
They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.
By purchasing from our Website the buyer accepts and acknowledges the risks involved with handling of these products.
All articles and product information provided on this Website are for informational and educational purposes only. Handling and use of these products should be restricted to suitably qualified professionals.
GHK-Cu (Copper Peptide) – Research Grade
For Research Use Only – Not for Human or Veterinary Use
What is GHK-Cu Peptide?
GHK-Cu, a tripeptide complex naturally found in the human plasma, is composed of glycine, histidine, and lysine bonded with copper. This peptide is integral to skin health and repair, as it stimulates collagen production, enhancing skin elasticity and firmness (1).
Its anti-inflammatory properties aid in reducing skin irritation and promote faster wound healing. Moreover, GHK-Cu supports hair growth by revitalizing hair follicles, making it beneficial in treating hair thinning (1).
Widely utilized in cosmetic and therapeutic applications, GHK-Cu is valued for its anti-aging benefits, offering comprehensive skin rejuvenation and contributing to healthier, more youthful-looking skin.
Molecular Formula: C14H24N6O4
Sequence: H-Gly-His-Lys-OH
Molecular Weight: 340.38 g/mol
View the HPLC Certificate here.
Source:
Summary of GHK-Cu Benefits:
During clinical studies GHK-Cu demonstrate the following potential benefits:
Enhances collagen production which can enhance skin elasticity and firmness (2).
Promotes wound healing of various soft tissues (1).
Decreases inflammation of skin which can reduce redness and inflamed skin (3).
Reduces the signs of aging through improving skin elasticity and firmness (4).
Supports hair growth (1).
Protects against oxidative stress (5).
Potential treatment for neurological diseases and cognitive impairment (6).
GHK-Cu Mechanism of Action
GHK-Cu peptide functions by interacting with cells to promote skin health and repair through several mechanisms. It binds copper ions, a crucial element for cellular processes, allowing GHK-Cu to enhance enzymatic activities essential for tissue regeneration.
This interaction stimulates collagen production, which is vital for maintaining skin elasticity and firmness (1).
This amino acids anti-inflammatory effects help reduce skin irritation and facilitate faster wound healing by modulating immune response and decreasing cytokine production.
Additional information suggests that GHK-Cu influences gene expression related to skin regeneration, activating genes that promote skin repair and recovery (3).
Its antioxidant properties further protective effects on skin cells from oxidative stress by neutralizing free radical damage, which is one of the primary contributors to premature aging and skin damage (5). Through these combined actions, GHK-Cu not only supports skin rejuvenation but also contributes to overall skin vitality, making it a valuable component in both cosmetic and therapeutic applications aimed at enhancing skin health and appearance.
Potential Clinical Applications of GHK-Cu Peptide
UK Laboratory studies have found that GHK-Cu that GHK-Cu can have the following clinical applications:
Enhances Collagen Synthesis
Studies have identified that GHK-Cu significantly enhances collagen production and offers anti-aging benefits by activating fibroblasts, the skin cells responsible for collagen synthesis. This results in increased production of collagen levels, improving skin elasticity and reducing the appearance of wrinkles (1). Its powerful antioxidant properties protect skin cells from oxidative stress, which can accelerate aging (5). Additionally, GHK-Cu prevents enzymes like matrix metalloproteinases that break down collagen, preserving the skin’s structural integrity. These combined actions contribute to a firmer, more youthful skin appearance, making GHK-Cu an essential ingredient in anti-aging skincare products.
Promotes Hair Growth
When used in a scalp serum treatment GHK-Cu promotes hair growth by stimulating hair follicles and improving blood flow to the scalp, ensuring essential nutrients reach the follicles (1). It reduces inflammation and oxidative stress, creating a healthier environment for hair growth. Additionally, GHK-Cu enhances collagen production, strengthening the scalp, improves hair follicle size and supports robust hair structure.
Accelerates Wound Healing
GHK-Cu, or Glycyl-L-histidyl-L-lysine copper, accelerates wound healing through several mechanisms. It stimulates the growth of skin cells like keratinocytes and fibroblasts, critical for tissue regeneration. By enhancing collagen production, GHK-Cu provides structural support to healing tissues (1). Its anti-inflammatory effects reduce swelling and promote a conducive healing environment. The peptide also promotes angiogenesis, forming new blood vessels that supply essential nutrients and oxygen to the wound (7). With antioxidant properties, it protects cells from oxidative stress, while its antimicrobial effects lower infection risks. These combined actions make GHK-Cu an effective ingredient in skincare products for wound repair.
Reduces Inflammation and Redness of the Skin
GHK-Cu reduces skin inflammation and redness through several effective mechanisms. It modulates inflammatory cytokines, thereby calming the skin’s inflammatory response and reducing redness (3). Its potent antioxidant properties help neutralize free radicals, protecting skin cells from oxidative stress that can exacerbate inflammation. Additionally, GHK-Cu promotes skin repair by stimulating the regeneration of healthy skin cells, reducing dead skin cells which aids in restoring the natural skin barrier, clarity and appearance (1). These combined actions make GHK-Cu a powerful ingredient in skincare products designed to soothe and improve skin health, offering relief from irritation and contributing to a clearer, more balanced complexion.
Potential Treatment for Cognitive Impairment
GHK-Cu may offer benefits for neurological problems through several promising mechanisms. It reduces oxidative stress, which is crucial for protecting nerve cells from damage associated with neurological disorders (6). Additionally, GHK-Cu promotes nerve regeneration by stimulating the repair and growth of neurons, potentially aiding in recovery from neural injuries. It also modulates inflammatory responses within the nervous system, helping to create a more balanced environment for neuron function (1). These combined actions suggest that GHK-Cu could contribute to neuroprotection and improved cognitive function, positioning it as a valuable compound for supporting neurological health and wellness.
GHK-Cu Frequently Asked Questions
What products is GHK-Cu found in?
The GHK-Cu peptide is found in many hair care, skin care products and dietary supplements. The copper peptide serum is commonly found in eye cream, face serum, moisturisers, vitamin c cream and some formulations containing hyaluronic acid. It is important to check the ingredient lists of products or check with a pharmacist.
What effects on the skin does GHK-Cu peptide products have?
As discussed above, GHK-Cu is extensively studied for its anti-aging effects on the skin. It has been found to improve skin density, thickness, reduce the depth of wrinkles and fine lines particularly around the eye area, reduce large pores, and improve elasticity. Furthermore, GHK-Cu may reduce the appearance of lesions and acne scars.
Can GHK-Cu skin serum reduce the effects of UV radiation?
Clinical trials demonstrate that GHK-Cu skin serum can help reduce the effects of UV radiation. The peptide aids in wound healing and reduces inflammation, which can be beneficial in mitigating the effects of UV exposure (1). a
Scientific Research
(1) Pickart L, Margolina A. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. Int J Mol Sci. 2018 Jul 7;19(7):1987.
(2) Pickart L, Vasquez-Soltero JM, Margolina A. GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration. Biomed Res Int. 2015;2015:648108.
(3) Park JR, Lee H, Kim SI, Yang SR. The tri-peptide GHK-Cu complex ameliorates lipopolysaccharide-induced acute lung injury in mice. Oncotarget. 2016 Sep 6;7(36):58405-58417.
(4) Dou Y, Lee A, Zhu L, Morton J, Ladiges W. The potential of GHK as an anti-aging peptide. Aging Pathobiol Ther. 2020 Mar 27;2(1):58-61.
(5) Pickart L, Vasquez-Soltero JM, Margolina A. The human tripeptide GHK-Cu in prevention of oxidative stress and degenerative conditions of aging: implications for cognitive health. Oxid Med Cell Longev. 2012;2012:324832.
(6) Tucker M, Keely A, Park JY, Rosenfeld M, Wezeman J, Mangalindan R, Ratner D, Ladiges W. Intranasal GHK peptide enhances resilience to cognitive decline in aging mice. bioRxiv [Preprint]. 2023 Nov 17:2023.11.16.567423.
(7) Tianqi Liu, Ying Liu, Xiaoyu Zhao, Liguo Zhang, Wei Wang, De Bai, Ya Liao, Zhenyuan Wang, Mi Wang, Jiaheng Zhang, Thermodynamically stable ionic liquid microemulsions pioneer pathways for topical delivery and peptide application, Bioactive Materials, Volume 32, 2024, Pages 502-513
(8) Malinda KM, Sidhu GS, Mani H, Banaudha K, Maheshwari RK, Goldstein AL, Kleinman HK. Thymosin beta4 accelerates wound healing. J Invest Dermatol. 1999 Sep;113(3):364-8.
Peptide Storage & Reconstitution
The Peptide Vial holds a white, lyophilised solid peptide that dissolves easily in clinical-grade sterile or bacteriostatic water.
To preserve the quality and stability of peptides, store them in a cool, dry place, away from heat and direct sunlight.
Refrigeration is highly recommended, with optimal storage temperatures between 2°C and 8°C.
Keeping peptides in tightly sealed vials or containers prevents exposure to air and moisture, which can compromise their quality.
Following these storage guidelines helps extend the shelf life of peptides, ensuring their reliability for research and therapeutic use.
ALL PRODUCT INFORMATION AND ARTICLES ON THIS SITE ARE FOR EDUCATIONAL PURPOSES ONLY
DISCLAIMER:
All products sold by Revitalife are for research and laboratory use only.
These products are not designed for use or consumption by humans or animals.
They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.
By purchasing from our Website the buyer accepts and acknowledges the risks involved with handling of these products.
All articles and product information provided on this Website are for informational and educational purposes only. Handling and use of these products should be restricted to suitably qualified professionals.